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Eliquis (apixaban) is used to prevent serious blood clots as it blocks the activity of clotting substances in the blood. In people with irregular heart rhythm (atrial fibrillation), it reduces the risk of stroke that can occur due to blood clotting. After a hip or knee replacement surgery, it is used to prevent DVT (deep vein thrombosis) which can lead to the formation of clots in the lungs (PE).