Buy Generic Comtan (Entacapone) Online

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About Generic Comtan® (Entacapone)

Key Details

1. Generic Comtan™ 200 mg for Parkinsons Disease
2. Buy online Generic Comtan™ 200 mg (30 Pills), Comtan Cost, Price $15.00 at 73% Discount
3. Prolongs levodopa effect
4. Reduces “wearing-off” phenomenon
5. Improves motor control

How Generic Comtan Works

After oral administration, entacapone inhibits the COMT enzyme in peripheral tissues. This enzyme normally metabolizes levodopa before it reaches the brain.

By preventing levodopa breakdown, more of it crosses the blood-brain barrier. This prolongs and enhances the effect of levodopa, improving motor symptoms in Parkinson’s disease.

Drug Info

ENTACAPONE – ORAL (en TA ka pone)
Common Brand Name(s): Comtan™

Other name brands for this medication
Entacom, Adcapone

Uses of Comtan

Entacapone is used in combination with levodopa/carbidopa to treat end-of-dose "wearing off" effect in patients with Parkinson's disease, sometimes called shaking palsy. Parkinson's disease is a disorder of the central nervous system (brain and spinal cord).

Dopamine is a naturally occurring substance in the brain that helps provide control of movement and activities such as walking and talking. In patients with Parkinson's disease, there is not enough dopamine in some parts of the brain. Entacapone helps levodopa last longer by blocking a substance called COMT enzyme. This enzyme breaks down levodopa before it reaches the brain. When less levodopa is broken down, more is available to the brain. Increased availability of levodopa may lead to smoother and steadier levels of dopamine in the brain, which may provide better symptom control for longer periods each day. This may lead to improvement in daily activities.

This medicine is available only with your doctor's prescription.

Before Using Comtan

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

How to Use Comtan

Take this medicine only as directed by your doctor, to help your condition as much as possible. Do not take more or less of it, and do not take it more or less often than your doctor ordered.

Take this medicine with or without food.

Side Effects of Comtan

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:
More common

    Absence of or decrease in body movements
    hyperactivity
    increase in body movements
    seeing, hearing, or feeling things that are not there
    twisting
    twitching
    uncontrolled repetitive movements of the tongue, lips, face, arms, or legs

Less common

    Cough or hoarseness
    fever or chills
    lower back or side pain
    painful or difficult urination

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Precautions

It is important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.
You should not use certain MAO inhibitors (such as phenelzine, tranylcypromine) while using this medicine.

Do not stop taking entacapone without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping completely.
This medicine may make you dizzy or drowsy. It may even cause you to fall asleep without warning while you drive, talk, or eat. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

This medicine will add to the effects of other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your medical doctor or dentist before taking any of the above while you are taking this medicine.

It is possible that you may become nauseous, especially when you are first starting your medicine.

Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. If you should have this problem, check with your doctor.

If you develop any unusual or strange thoughts and behavior while receiving this medicine, be sure to discuss it with your doctor. Other changes might be confusion, worsening of depression, visual hallucinations (seeing things that are not there), suicidal thoughts, and unusual excitement, nervousness, or irritability.
Some people who have used this medicine had unusual changes in their behavior. Talk with your doctor right away if you start having problems with gambling or an increased interest in sex while using this medicine.

This medicine may cause diarrhea, and in some cases it can be severe. It can occur months after starting this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.
Check with your doctor right away if you have dark-colored urine, fever, muscle cramps or spasms, muscle pain or stiffness, or unusual tiredness or weakness. These may be symptoms of a condition called rhabdomyolysis.

Check with your doctor right away if you are having convulsions (seizures), difficulty with breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

It is important that your doctor check your skin regularly for signs of a skin cancer called melanoma. If you notice any unusual red, brown, or black spots on your skin, talk to your doctor right away.
This medicine may cause your urine to turn brownish orange. This is normal and nothing to worry about.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

    Furazolidone
    Iproniazid
    Isocarboxazid
    Linezolid
    Methylene Blue
    Nialamide
    Pargyline
    Phenelzine
    Procarbazine
    Tranylcypromine

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea, vomiting, fast or irregular heartbeat, unusual drowsiness or dizziness, and loss of consciousness.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Cost of Comtan

The lowest MyGenericPharmacy.com price for the most common version of Comtan (Entacapone) is around $0.50, 73% off the average online retailing price of $55.80.

What is Comtan / Entacapone?
Comtan is a medication containing entacapone, used as an adjunct treatment in Parkinson’s disease. It is given with levodopa to enhance its effect and reduce “wearing-off” symptoms.

How Does Comtan Work?
Entacapone is a catechol-O-methyltransferase (COMT) inhibitor. It blocks the peripheral breakdown of levodopa, increasing its availability to the brain.

Benefits of Comtan

1. Prolongs levodopa effect
2. Reduces “wearing-off” phenomenon
3. Improves motor control
4. Enhances dopamine availability indirectly
5. Improves quality of life

Dosage & How to Use

1. Taken orally as tablets
2. Usual dose: 200 mg with each dose of levodopa
3. Maximum: up to 8 doses/day
4. Always used in combination with levodopa/carbidopa
5. Dose adjusted based on response

Side Effects & Precautions
Common side effects may include:

1. Dyskinesia
2. Nausea
3. Diarrhea
4. Urine discoloration (orange/brown)
5. Dizziness

Precautions:

1. Always use with levodopa
2. Monitor for dyskinesia (may need levodopa dose adjustment)
3. Use caution in liver disease
4. Monitor blood pressure
5. Avoid abrupt discontinuation

Who Should Not Take Comtan

1. Patients with hypersensitivity to entacapone
2. Individuals with severe liver disease
3. Patients with history of neuroleptic malignant syndrome (caution)

Other Information of Comtan :
FOR BEST RESULTS, this medicine should be used along with exercise, a low-cholesterol/low-fat diet, and a weight loss program if you are overweight. FOLLOW THE DIETARY PLAN provided by your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children and pets. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.

MISSPELLINGS OF COMTAN :
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Entacapohn, Entecapon, Entecappone, Entacaponne.

FAQ

1. What is Entacapone (Comtan) and what is it used for?
Entacapone is a medical drug available to us under the brand name Comtan is a member of the class of medication called nitrocatechol. It is a medication that is used as a combination with several other medicines for the treatment of neurological disease called Parkinson's disease.

2. When to use Entacapone?
Entacapone arrives as a tablet that must be taken by mouth as per your doctor's prescription. You can take this medicine before or after the meal. Initially, your doctor may start the dosage at a low level. This is recommended so that there is least possibility of side effects. The dosage may increase after a few days. There is no fixed time or fixed number of dosages. Do not increase the dosage or take it more often than prescribed. Follow the prescription label provided by the medicine and consult your doctor in case of any confusion.

3. What are side effects of Entacapone?
Side effects of Entacapone are restless muscle movements in your eyes, tongue, jaw, or neck, hallucinations, very stiff/rigid muscles, high fever, sweating, fast or uneven heartbeats, tremors, feeling like you might pass out, muscle pain, tenderness/weakness, fever, unusual tiredness, and dark colored urine, diarrhea, stomach pain, dizziness, drowsiness etc. Contact your doctor immediately in case you observe any of these side effects or other.

4. How effective is Entacapone?
Entacapone is a medication that treats the symptoms of Parkinson's disease. This medicine is not a cure but maintains the effects of the following disease symptoms. This medicine's effectiveness has been remarkably increased in patients dealing with no end of dose. As it is a medicine that has its effects on the brain, it must be used and consulted by a doctor carefully or else it may lead to some severe side effects.

5. How quickly does Entacapone work?
Entacapone is a kind of medicine that is very quick when comes to its onset of action against the symptom. The peak plasma concentration of this medicine is achieved within an hour after the intake of medicine. This medicine is generally used for a long term.

6. Which drugs interact with Entacapone?
Interaction with a medicine generally refers to a change of effectiveness and potential risk that could develop when two or more different drugs come into contact with one another inside the body. Drugs that interact with Entacapone include MAO inhibitors, selegiline, safinamide, etc. Medicines that could affect the removal of Entacapone from the body thereby affecting its working are methyldopa, dobutamine, apomorphine, and many more. 

7. Does entacapone cause dyskinesia?
Entacapone may trigger the side effect of levodopa when used together that may cause or amplifies the preexisting dyskinesia. Patients continue to get frequent dyskinesia even when the dose of levodopa is decreased as per studies.

8. Can Entacapone cause hallucinations?
Entacapone is a kind of medicine that could make you develop unusual and strange thoughts and behavior. One must inform the doctor if observe such symptoms. Other possibilities include visual hallucinations, confusion, suicidal thought, worsening of depression, irritability, nervousness, etc.

9. Does Entacapone affect blood pressure?
While medicating with Entacapone. one can easily get dehydrated. This could lead to serious electrolyte imbalance or low blood pressure(Hypotension) in the body. One must inform the doctor if such a condition persists or get worse than usual.

10. What precautions must be taken before medicating with Entacapone?
Before starting the medication with Entacapone, one must inform the doctor regarding allergies related to it, or any other allergies as these products may contain some ingredient that causes an allergic reaction inside your body. Inform your doctor if you have a medical history related to liver problems, kidney disease, sleep disorders, mental/mood disorders, low blood pressure, alcoholism, etc. 

11. Can a pregnant woman use Entacapone?
Entacapone is a kind of medicine that must only be used when needed during pregnancy. One must consult with their health professional before medicating with Entacapone. Also, it is not known whether the medicine gets passed on to breast milk or not. Consult your doctor before breastfeeding the baby.