Buy Generic Valdoxan (Agomelatine) Online

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About Generic Valdoxan® (Agomelatine)

Key Details

1. Generic Valdoxan™ 25mg for Anti Depressant
2. Buy online Generic Valdoxan™ 25 mg (30 Pills), Valdoxan Cost, Price $27.30 at 56% Discount
3. Improves mood, reduces sadness, fatigue, and emotional numbness.
4. Helps restore natural sleep without causing daytime drowsiness.
5. Lower risk of sexual side effects compared to SSRIs/SNRIs.

How Generic Valdoxan Works

Generic Valdoxan (Agomelatine) works by targeting the brain’s melatonin receptors (MT1 and MT2), which play an important role in regulating the sleep–wake cycle and the body’s circadian rhythm. By stimulating these receptors, it helps normalize disrupted sleep patterns that commonly occur in depression. Patients often experience better sleep quality, easier sleep onset, and fewer early-morning awakenings without feeling sedated during the day.

In addition to its effect on melatonin receptors, Agomelatine also blocks the 5-HT2C serotonin receptors, which increases the release of dopamine and norepinephrine in the frontal areas of the brain. These neurotransmitters are closely linked to motivation, energy, focus, and emotional regulation. By boosting them in a targeted way, Valdoxan helps elevate mood, reduce anxiety symptoms, and restore mental balance.

This dual mechanism makes Generic Valdoxan unique compared to traditional antidepressants. It improves both sleep and mood without directly altering serotonin levels, which leads to fewer sexual side effects, minimal weight changes, and no significant withdrawal symptoms. This combination of benefits contributes to its effectiveness for people with major depressive disorder, especially when sleep disturbance is a major concern.

Drug Info

AGOMELATINE– ORAL (a-go-ME-la-tine)
Common Brand Name(s): Valdoxan™

Other name brands for this medication
Agoprex, Noveltin, Agopose, Agoviz, Agodep, Lupibliss, Agotine, Circaltin

Uses of Valdoxan

Agomelatine was expected to be used in adult patients to treat major depressive disorder. In major depressive disorder, patients have disturbances of mood that interfere with their everyday life. They may suffer from deep sadness, feelings of worthlessness, loss of interest in favourite activities, sleep disturbances, feeling of being slowed down, feelings of anxiety, changes in weight. The key symptoms are depressed mood and loss/diminished interest or pleasure. Patients often suffer relapses (when the disease comes back after it has been treated).

Before Using Valdoxan

Before taking agomelatine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

How to Use Valdoxan

Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller quantities than prescribed. Contact your doctor if symptoms do not improve after a week of therapy with this medicine. Swallow it as a whole. Do not chew, crush or break it. Agoprex Tablet may be taken with or without food, but it is better to take it at a fixed time.

Side Effects of Valdoxan

There are some common side effects such as:

Headache
Nausea
Dizziness
Fatigue
Anxiety
Insomnia (Difficulty In Sleeping)
Back Pain
Abdominal Pain
Change In Body Weight
Diarrhoea
Constipation
Sleepiness
Increased Liver Enzymes

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

This medicine should be used with caution in patients who are at risk of liver injuries such as diabetic patients, obese or overweight patients, etc. due to the increased risk of liver damage. Regular assessment of liver function is necessary before initiating the therapy with this medicine and during the therapy. Replacement with a suitable alternative may be necessary in some cases based on the clinical condition of the patient.

Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential risks and benefits associated with the use of this medicine.

Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Drug Interactions

Agomelatine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Cost of Valdoxan

The lowest MyGenericPharmacy.com price for the most common version of Valdoxan (Agomelatine) is around $0.91, 56% off the average online retailing price of $62.10.

What is Valdoxan / Agomelatine?
Valdoxan (Agomelatine) is an atypical antidepressant used to treat major depressive disorder (MDD) in adults, working uniquely by stimulating melatonin receptors (MT1 & MT2) to regulate the sleep–wake cycle while blocking the 5-HT2C serotonin receptor to increase dopamine and norepinephrine levels in the brain. This dual action helps improve mood, reduce anxiety, restore natural sleep patterns, and boost overall emotional well-being, with fewer sexual side effects, minimal weight gain, and no significant withdrawal symptoms compared to many traditional antidepressants.

How Does Valdoxan Work?
Valdoxan works by resetting the body’s sleep–wake cycle through melatonin receptors and boosting mood by increasing dopamine and norepinephrine through 5-HT2C receptor blockade. This combination improves sleep quality and lifts depression symptoms.

Benefits of Valdoxan

1. Improves mood, reduces sadness, fatigue, and emotional numbness.
2. Helps restore natural sleep without causing daytime drowsiness.
3. Lower risk of sexual side effects compared to SSRIs/SNRIs.
4. No significant weight gain for most users.

Dosage & How to Use

1. Usually 25 mg once nightly, taken at bedtime.
2. Can be increased to 50 mg at night if needed.
3. Must be taken regularly, not as-needed.

Side Effects & Precautions
Common side effects may include:

1. Headache
2. Nausea
3. Dizziness
4. Abnormal dreams
5. Anxiety or restlessness

Precautions:

1. Avoid alcohol (increases liver strain).
2. Regular LFTs before starting, and during treatment.
3. Inform doctor if you have liver disease, sleep disorders, bipolar disorder, or are taking strong CYP1A2 inhibitors.

Who Should Not Take Valdoxan

1. People with liver impairment
2. Those taking fluvoxamine or ciprofloxacin
3. Heavy alcohol users
4. Those with uncontrolled bipolar disorder (risk of mania)

Other Information of Valdoxan :
FOR BEST RESULTS, this medicine should be used along with exercise, a low-cholesterol/low-fat diet, and a weight loss program if you are overweight. FOLLOW THE DIETARY PLAN provided by your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children and pets. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.

MISSPELLINGS OF VALDOXAN :
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Agomelatiene.

FAQ

1. What is Agomelatine and what is it used for?
Agomelatine is a medical drug that belongs to a class of medication called melatonin agonist. This medicine is generally used to treat MDD (Major Depressive Disorders. The drug works by blocking and stimulating certain receptors and is thought to increase neurotransmitters in the brain such as dopamine and noradrenaline.

2. When and how to use Agomelatine?
Agomelatine is available to us in a form of pill that must be taken by mouth with or without food as per your doctor's prescription. An ideal dose of one tablet daily at bedtime is generally prescribed. The dosage is based on your medical condition, its response to the treatment, and other medicine that you may be taking along with Agomelatine. Take the medicine at the same time daily to get the most benefits from it. Do not increase the dosage or take it more often than prescribed. Contact your doctor in case of any confusion or exception associated with medication.

3. What are the side effects of using Agomelatine?
Side effects observed while medicating with Agomelatine are anxiety, stomach pain, insomnia, drowsiness and fatigue, change in bowel habit, changes in liver enzymes, nausea and vomiting, abnormal dreams, dizziness, weight gain, etc. Inform your doctor if these conditions persist or get worse.

4. Is agomelatine the same as melatonin?
Agomelatine is a synthetic analogue of melatonin. The manufacturer claims that Agomelatine agonises melatonin as well as serotonin receptors.

5. Does agomelatine help with sleep?
Agomelatine is useful in improving sleep quality at night as it mimics the natural rhythm of melatonin release. However, it is a weak agonist that increases noradrenaline and dopamine release.

6. Can you stop agomelatine?
Agomelatine is a kind of drug that may cause worsening of depression if stopped suddenly. The medicine must be withdrawn as per procedure provided by the doctor.

7. Does agomelatine cause hair loss?
Agomelatine is likely to cause hair loss after 2-3 months of daily medication. The mechanism of Agomelatine seems to act by inducing premature telogen that results in hair loss.

8. Can a pregnant woman use Agomelatine?
Agomelatine is a kind of medicine that must only be used when clearly needed during pregnancy. The risk and benefits associated with the medicine must be discussed before the onset of the treatment. Medicating with Agomelatine at least 3 months of pregnancy could cause the child unwanted harmful effects.

9. Is Agomelatine safe during breastfeeding?
It is unknown whether Agomelatine gets passed on to the breast milk or not during its medication. Therefore, it is necessary to consult a doctor regarding the potential risk to the child from Agomelatine before breastfeeding the baby.

10. How long does Agomelatine take to work?
Agomelatine is a kind of medicine that does not work instantly. According to reports, Agomelatine takes around 4 weeks to deliver its maximum effect on the symptom. However, you can expect initial relief in depression within the first 2 week of medication.