Buy Generic Tykerb (Lapatinib) Online

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About Generic Tykerb® (Lapatinib)

Key Details

1. Generic Tykerb™ 250 mg for Cancer
2. Buy online Generic Tykerb™ 250mg (30 Pills), Tykerb Cost, Price $459.00 at 50% Discount
3. Effective in HER2-positive breast cancer
4. Oral targeted therapy
5. Useful after trastuzumab failure

How Generic Tykerb Works

Generic Tykerb targets HER2-overexpressing breast cancer cells by blocking intracellular kinase activity. This prevents activation of pathways such as PI3K/Akt and MAPK that drive tumor growth.

Unlike trastuzumab, lapatinib works intracellularly and can cross the blood–brain barrier to some extent. This makes it useful in advanced disease and brain metastases.

Drug Info

LAPATINIB– ORAL (la PA ti nib)
Common Brand Name(s): Tykerb™

Other name brands for this medication
Herlapsa, Abnib, Etibo, Lapahope, Tylidys, Her-Tinib, Lupidoc, Libset, Combinib

Uses of Tykerb

After receiving treatment with various cancer drugs, advanced hormone-related breast cancer that has progressed or spread is treated with lapatinib.

Lapatinib is only prescribed for this problem if a protein called human epidermal growth factor receptor 2 is present in your tumour (HER2). Cancer cell proliferation can be accelerated by the HER2 protein.

Lapatinib is administered in conjunction with the hormone medication letrozole to postmenopausal women (Femara). In some cases, lapatinib is used with the anticancer drug capecitabine (Xeloda).

Before Using Tykerb

Before taking lapatinib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.  

How to Use Tykerb

Before using lapatinib and each time you get a refill, read the Patient Information Leaflet that was given to you by your pharmacist. You should speak with your doctor or pharmacist if you have any questions.

Take this medicine orally. One meal each day, usually an hour before or an hour after, or as your doctor instructs. It's crucial that you just take this prescription once each day.

The dosage is determined by your medical history, treatment response, and any additional medications you may be taking.

Do not use this medication in larger amounts or more frequently than recommended. Your disease won't get better any faster, and there's a chance that you'll experience more severe side effects.

Except as directed by your doctor, refrain from consuming grapefruit or grapefruit juice while taking this medication. Certain drugs can circulate in your circulation more frequently if you eat grapefruit. For more information, speak with your doctor or pharmacist.

Women who are or may become pregnant should not handle this medication or breathe the dust from the pills because it can be absorbed via the skin and lungs.

Be sure to take capecitabine or letrozole with lapatinib as directed by your doctor.

Side Effects of Tykerb

It is possible to experience nausea, vomiting, upset stomach, mouth sores, minor rash, dry skin, and difficulty sleeping. Inform your doctor or pharmacist as soon as possible if any of these side effects persist or get worse.

The adverse effect of diarrhoea is common and can get really bad. If you get diarrhoea or exhibit dehydration-related symptoms including lightheadedness or reduced urine, call your doctor straight away. To assist you regulate your symptoms, your doctor should recommend additional medications. Your doctor might need to discontinue or postpone your lapatinib treatment if your diarrhoea worsens.

When using this medication, it's possible that your hands or feet could have hand-foot syndrome, a cutaneous response (palmar-plantar erythrodysesthesia). If your hands or feet start to swell, hurt, turn red, peel, blister, or feel tingly or burning, call your doctor immediately away. Heat or pressure on your hands or feet might exacerbate the discomfort. Avoid spending too much time in the sun, tanning beds, and sunlamps, as well as overheating (such as hot dishwater, long hot baths). When outside, wear protective gear and sunscreen. Avoid applying pressure to the knees, feet, or elbows (such as leaning on elbows, kneeling, taking long walks). Put on comfy shoes and loose clothing. Your doctor may prescribe an additional drug to treat your hand-foot syndrome, stop or postpone your lapatinib treatment, or both, depending on how bad the condition is.

Keep in mind that your doctor has recommended this medication because they believe it will benefit you more than it will harm you. Many users of this medicine report no significant negative effects.

If you have any severe side effects, such as extreme fatigue, shortness of breath, or swelling in your ankles or feet, call your doctor straight away.

If you have any extremely significant side effects, including as a rapid, pounding, or irregular heartbeat, fainting, or dizziness, seek medical attention right away.

Rarely will this medication cause a very serious allergic reaction. However, if you experience any major adverse reaction symptoms, such as a rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing, seek medical attention right away.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Inform your doctor or pharmacist about all of your current medications, especially any you are taking for liver or heart problems.

A disease that alters the heart rhythm could be brought on by lapatinib (QT prolongation). Rarely, QT prolongation can result in fast/irregular heartbeat that is significant (rarely fatal) and other symptoms including acute dizziness and fainting that require immediate medical intervention.

If you take other medications or have certain medical problems that could raise your risk of QT prolongation, you should consult your doctor. The following conditions should be disclosed to your doctor or pharmacist before to using lapatinib: certain heart issues (heart failure, sluggish heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Your risk of QT prolongation may also increase if your blood contains too little potassium or magnesium. This risk could rise if you take specific medications (such diuretics or "water pills") or experience symptoms like excessive sweating, diarrhoea, or vomiting. Ask your doctor for advice on how to use lapatinib safely.

Elderly people might be more sensitive to this medication's adverse effects, particularly QT prolongation (see above).

If you are pregnant or want to become pregnant, let your doctor know. Pregnancy should not occur when taking lapatinib. Lapatinib may be harmful to an unborn child. When using this drug, both women and men should inquire about effective methods of birth control, both throughout therapy and for one week after quitting it. Consult your doctor right away about the dangers and advantages of this drug if you or your partner becomes pregnant.

It is unclear whether this medication enters breast milk. Breastfeeding is not advised while taking this medicine and for 1 week after quitting it because of the potential harm to the baby. Before breastfeeding, speak with your doctor.

Drug Interactions

Drug interactions could alter how your medications function or raise the possibility of major negative side effects. All probable medication interactions are not included in this document. Keep a list of everything you use, including herbal products, prescription and over-the-counter medications, and provide it to your doctor and pharmacist. Without your doctor's approval, never start, stop, or change the dosage of any medications.

Other medications' effectiveness may be impacted by how slowly this drug is removed from your body. Several "statin" cholesterol treatments (simvastatin, lovastatin, atorvastatin), digoxin, irinotecan, tacrolimus, and trazodone are examples of impacted medications.

The elimination of lapatinib from your body can be impacted by other medications, which may change how lapatinib functions. Dexamethasone, cimetidine, St. John's wort, azole antifungals like itraconazole and ketoconazole, macrolide antibiotics like erythromycin and clarithromycin, HIV protease inhibitors like ritonavir and saquinavir, rifamycins like rifabutin, and some anti-seizure medications like phenytoin are a few examples.

Along with lapatinib, many other medications, such as dofetilide, pimozide, procainamide, amiodarone, quinidine, sotalol, and macrolide antibiotics (such as erythromycin), among others, may influence the cardiac rhythm (QT prolongation). Inform your doctor or pharmacist of all medications you are presently taking prior to taking lapatinib.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Cost of Tykerb

The lowest MyGenericPharmacy.com price for the most common version of Tykerb (Lapatinib) is around $15.30, 50% off the average online retailing price of $920.10.

What is Tykerb / Lapatinib?
Tykerb is an oral targeted anticancer medication used in HER2-positive advanced or metastatic breast cancer, usually in combination with capecitabine or letrozole. It is prescribed when disease progresses after prior HER2-directed therapy.

How Does Tykerb Work?
Lapatinib is a dual tyrosine kinase inhibitor that blocks HER2 (ErbB2) and EGFR (ErbB1) receptors. This inhibits downstream signaling pathways responsible for tumor cell proliferation and survival.

Benefits of Tykerb

1. Effective in HER2-positive breast cancer
2. Oral targeted therapy
3. Useful after trastuzumab failure
4. Dual HER2 and EGFR inhibition
5. Can be combined with chemotherapy or endocrine therapy

Dosage & How to Use

1. Taken orally once daily
2. Typical dose: 1,250 mg once daily (with capecitabine)
3. With letrozole: 1,500 mg once daily
4. Take on an empty stomach
5. Swallow tablets whole with water

Side Effects & Precautions
Common side effects may include:

1. Diarrhea
2. Rash
3. Nausea
4. Fatigue
5. Decreased appetite

Precautions:

1. Monitor liver function tests
2. Assess cardiac function before and during therapy
3. Manage diarrhea aggressively
4. Avoid strong CYP3A4 inhibitors/inducers

Who Should Not Take Tykerb

1. Hypersensitivity to lapatinib
2. Severe hepatic impairment
3. Pregnancy and breastfeeding
4. Uncontrolled cardiac disease

Other Information of Tykerb :
DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children.

MISSPELLINGS OF TYKERB :
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Tykrb, Tykerb, Tykrbe, Tykarb, Lapatinibb, Lapatinibx, Lapatinibe, Lapatnib, Lapatinibee, Lapatinibz, Lapatinibe, Lapatinib, Lapatnibb, Lapatnibe, Lapatinibx, Lapatinibaa, Lapatinibex, Lapatinibee, Lapatenib, Lapatinibbe, Lapataneeb, 
Lapatinip.

FAQ

1. What is Lapatinib and its use?
Lapatinib is a medical drug that belongs to a class of medication called Kinase inhibitors. It functions by preventing the aberrant protein from signalling the growth of cancer cells. This aids in halting or reducing the growth of cancer cells.

2. Is lapatinib a chemotherapy drug?
GlaxoSmithKline (GSK) created the anti-cancer medication lapatinib as a treatment for solid tumours like breast and lung cancer. On March 13, 2007, the FDA gave its approval for use in conjunction with the chemotherapeutic medication capecitabine in patients with advanced metastatic breast cancer.

3. When should I stop taking lapatinib?
Your doctor might need to discontinue or postpone your lapatinib treatment if your diarrhoea worsens. When using this medication, it's possible that your hands or feet could have hand-foot syndrome, a cutaneous response (palmar-plantar erythrodysesthesia).

4. What tests are done before lapatinib?
Transaminases, bilirubin, and alkaline phosphatase levels should be checked prior to starting medication, every 4 to 6 weeks while on treatment, and as clinically necessary.

5. Does lapatinib cross the blood brain barrier?
Lapatinib's tiny molecular form allows it to pass through the blood-brain barrier. When used alone or in combination, lapatinib has been found to stop the growth of brain metastases in breast cancer.

6. How does lapatinib work?
Lapatinib works by preventing the cancer cells' internal signals from growing and dividing. The signals die when they are blocked. Two proteins' actions are inhibited by lapatinib: Epidermal growth factor receptor, or erbB1 (EGFR).

7. When to take lapatinib?
Administer this drug orally. One meal each day, usually an hour before or an hour after, or as your doctor instructs. Swallow the tablet whole rather than chewing or crushing it in your mouth. Take the medicine at the same time daily to get the most benefits from it.