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About Generic Ofev® (Nintedanib)

Key Details

1. Generic Ofev™ 100 mg for Lung Disease
2. Buy online Generic Ofev™ 100 mg (10 Pills), Ofev Cost, Price $46.00 at 46% Discount
3. Slows progression of pulmonary fibrosis
4. Reduces decline in lung function (FVC)
5. Effective in multiple fibrosing ILDs

How Generic Ofev Works

After oral administration, nintedanib inhibits multiple tyrosine kinases that are involved in signaling pathways responsible for fibrosis. These include growth factor receptors that stimulate fibroblast activity.

By blocking these pathways, nintedanib reduces fibroblast proliferation, migration, and transformation. This slows down the progression of lung scarring and helps preserve lung function in fibrotic lung diseases.

Drug Info

NINTEDANIB – ORAL (nin TED a nib)
Common Brand Name(s): Ofev™

Other name brands for this medication
Cyendiv, Nintenib, Trofev, Fibnib, Macdanib, Nindev, Nindanib, Nintabid, Nintena, Mantedanib

Uses of Ofev

Nintedanib is used to treat idiopathic pulmonary fibrosis. It helps prevent changes to the lung tissue. It is also used to treat people with a chronic (long-lasting) interstitial lung disease in which lung fibrosis continues to progress or becomes worse. This medicine is also used to slow the rate of decline in lung function in people with systemic sclerosis-associated interstitial lung disease. Nintedanib belongs to the group of drugs called tyrosine kinase inhibitors.

Before Using Ofev

Before taking nintedanib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

How to Use Ofev

Read the Patient Information Leaflet if available from your pharmacist before you start taking nintedanib and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with food as directed by your doctor, usually twice daily (about 12 hours apart). The dosage is based on your medical condition and response to treatment. Follow your doctor's instructions carefully.

Swallow the capsule whole. Do not crush or chew because the drug has a bitter taste. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Tell your doctor if your condition worsens.

Side Effects of Ofev

Diarrhea, nausea, vomiting, abdominal pain, decreased appetite, and weight loss may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Diarrhea, nausea, and vomiting can be persistent and/or severe. Your doctor may have you drink more fluids if these symptoms occur and prescribe medications to treat the diarrhea, nausea, and vomiting.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Your doctor may control your blood pressure with medication.

Tell your doctor right away if you have any serious side effects, including: unusual bruising/bleeding, cough/stuffy chest, symptoms of liver problems (such as dark urine, yellowing eyes/skin).

Get medical help right away if you have any very serious side effects, including: symptoms of a heart attack (such as chest/jaw/left arm pain, unusual sweating), symptoms of a stroke (such as weakness on one side of body, sudden vision problems, trouble speaking), sudden/severe back pain or headache, severe stomach/abdominal pain, abdominal swelling.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, heart disease (such as chest pain, heart attack), high blood pressure, blood clots, bleeding problems, blood vessel problems (such as an aneurysm or a tear/break in the aorta or other blood vessels), recent abdominal surgery, stomach/intestinal problems (such as ulcers, diverticular disease).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using nintedanib. Nintedanib may harm an unborn baby. Your doctor should order a pregnancy test before you start this medication. Ask about reliable forms of birth control (such as condoms) while using this medication and for at least 3 months after stopping treatment. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.

It is unknown if nintedanib passes into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen/naproxen, "blood thinners" such as warfarin/dabigatran).

Aspirin can increase the risk of bleeding when used with this medication. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually 81-162 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

Other medications can affect the removal of nintedanib from your body, which may affect how nintedanib works. Examples include rifamycins (such as rifampicin), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others.

Cigarette smoking decreases blood levels of this medication. Tell your doctor if you smoke or if you have recently stopped smoking.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea, vomiting, fast or irregular heartbeat, unusual drowsiness or dizziness, and loss of consciousness.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Cost of Ofev

The lowest MyGenericPharmacy.com price for the most common version of Ofev (Nintedanib) is around $4.60, 46% off the average online retailing price of $85.80.

What is Ofev / Nintedanib?
Ofev is a medication containing nintedanib, used to treat idiopathic pulmonary fibrosis (IPF) and other fibrosing interstitial lung diseases. It helps slow the progression of lung fibrosis and decline in lung function.

How Does Ofev Work?
Nintedanib is a tyrosine kinase inhibitor. It blocks receptors such as VEGF, PDGF, and FGF involved in fibrogenesis.

Benefits of Ofev

1. Slows progression of pulmonary fibrosis
2. Reduces decline in lung function (FVC)
3. Effective in multiple fibrosing ILDs
4. Anti-fibrotic action
5. Helps preserve lung capacity

Dosage & How to Use

1. Taken orally as capsules
2. Usual dose: 150 mg twice daily
3. Take with food
4. Swallow whole, do not crush
5. Dose adjustments may be needed

Side Effects & Precautions
Common side effects may include:

1. Diarrhea (very common)
2. Nausea
3. Vomiting
4. Abdominal pain
5. Elevated liver enzymes

Precautions:

1. Monitor liver function tests regularly
2. Take with food to reduce GI effects
3. Maintain hydration (due to diarrhea)
4. Use caution in bleeding disorders
5. Avoid smoking (may reduce effectiveness)

Who Should Not Take Ofev

1. Patients with severe liver impairment
2. Individuals with hypersensitivity to nintedanib
3. Use caution in patients at risk of bleeding

Other Information of Ofev :
FOR BEST RESULTS, this medicine should be used along with exercise, a low-cholesterol/low-fat diet, and a weight loss program if you are overweight. FOLLOW THE DIETARY PLAN provided by your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children and pets. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out

MISSPELLINGS OF OFEV :
Ofev, Offev, Ofevv, Oev, Ofe, Ofevv, Ofevve, Ofve, Ofef, Ofev1, Ofvev, Ofav, 
Ofevv, Ofeve, Ofiv, Ofevh, Ovef, Ufev, Nintedanib, Nintadanib, Nintedinib, Nintendanib, Nintidanib, Nintedannib, Nintadainib, Nintadenib, Nintidaneb, Nintednib, Nintadib, Nintedannib, Nintedanibb, Nintedanip, Nintedonib, 
Nintedaneb, Nintedanyb, Nintidanib.

FAQ

1. What is Nintedanib and what is it used for?
Nintedanib is a medical drug that belongs to a class of medication called Kinase Inhibitors. This medicine is generally used to treat certain types of lung associated diseases. It works by reducing or resisting the worsening of lung disease.

2. When and how to use Nintedanib?
Nintedanib is available to us in a form of pill that must be taken by mouth as per your doctor's direction. Take this medicine with food or milk in case you are dealing with an upset stomach. The dosage is based on your medical condition and its response to the same.Take this medicine regularly to get the most benefits from it or as per your schedule at the same interval. Do not stop taking this medicine intinctly without consulting with your doctor as it may lead to some sudden withdrawal effects on your body.

3. What are the side effects of using Nintedanib?
Some of the common side effects observed while medicating with Nintedanib are Nausea, vomiting, diarrhea, decreased appetite, abdominal pain, weight loss, etc. Inform your doctor if these conditions persist or get worse. There are also some severe and rare allergies which require immediate medical attention if observed like symptoms of liver disease, symptoms of stroke or heart attack, cough/stuffy chest, rash, severe dizziness, trouble breathing, rash, itching/swelling, etc.

4. What precautions must be taken before using Nintedanib?
Before mediating with Nintedanib, one must inform the doctor regarding allergy to the medicine, its ingredient, or any other allergies. Inform your doctor regarding any medical condition or history related to high blood pressure, liver diseases, blood clots, heart diseases, recent abdominal surgery, stomach/intestinal problems, etc. Use of alcohol and marijuana can make you more dizzy than usual. Also, inform your doctor regarding all the drugs you may be taking before undergoing any surgery.

5. Can a pregnant woman use Nintedanib?
Nintedanib must not be used during pregnancy. The medicine could harm an unborn child or cause unfortunate complications. One must use Nintedanib only if the benefits of medicine outweighs the potential risk to the nursing child.

6. Is Nintedanib safe during breastfeeding?
It is unknown whether Nintedanib gets passed on to the breast milk or not during its medication. Therefore, it is necessary to consult a doctor regarding the potential risk to the child from Nintedanib before breastfeeding the baby.

7. Does nintedanib suppress the immune system?
Yes. Nintedanib is a kind of medicine that works as an immunosuppressant by affecting your body's immune system. It also reduces the amount of fibrosis in the lungs which helps in relieving symptoms of lung disease.

8. How long does Nintedanib take to work?
According to new studies, Nintedanib has a potency to slow down the progression of appropriate disease for upto 3 years. It is effective in mild, moderate, and severe stages of disease. This medicine is a well tolerated therapy for upto 3 years.