Buy Generic Prograf (Tacrolimus) Online

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About Generic Prograf® (Tacrolimus)

Key Details

1. Generic Prograf™ 1 mg for Immuno Suppressant
2. Buy online Generic Prograf™ 1 mg (30 Pills), Prograf Cost, Price $66.60 at 63% Discount
3. Prevents organ transplant rejection
4. Strong immunosuppressive effect
5. Improves graft survival

How Generic Prograf Works

After oral administration, tacrolimus binds to an intracellular protein (FKBP-12), forming a complex that inhibits calcineurin. This prevents activation of T-lymphocytes, which are responsible for immune-mediated organ rejection.

By suppressing T-cell activity, tacrolimus reduces the immune system’s ability to attack transplanted organs. This helps maintain graft survival and function after transplantation.

Drug Info

TACROLIMUS – ORAL (ta KRO li mus)
Common Brand Name(s): Prograf™

Other name brands for this medication
Envarsus XR, Astagraf XL, Hecoria, Protopic, Tacroz, Tacrovera, Takfa, Tacrotor, Tbis, Tacvido, Talimus, Topgraf

Uses of Prograf

Tacrolimus is used with other medications to prevent rejection of a kidney, heart, or liver transplant. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to treat a certain type of bowel condition (fistulizing Crohn's disease) in patients who cannot take or have not been successfully treated by the usual treatment. This medication may also be used to prevent rejection of other types of transplant (such as lung).

Before Using Prograf

Before taking tacrolimus, tell your doctor or pharmacist if you are allergic to it; or to other macrolide medications (such as sirolimus, erythromycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

How to Use Prograf

Take this medication by mouth with or without food, usually every 12 hours or as directed by your doctor. If you have nausea or an upset stomach, you may take this drug with food, although this may cause your body to absorb less of the drug. However, you must choose one way (with food or without food) and always take this medication the same way so that your body always absorbs the same amount of drug. Consult your doctor or pharmacist for more details.

Dosage is based on your weight, medical condition, blood test results (e.g., tacrolimus trough levels), and response to therapy. Do not increase your dose or take this medication more often without your doctor's approval. Your condition will not improve any faster and the risk of serious side effects may be increased. Also, do not stop taking this medication without your doctor's approval.

Take this medication regularly in order to get the most benefit from it. It is important to take all doses on time to keep the amount of medicine in your body at a constant level. Remember to take it at the same times each day. Avoid eating grapefruit or drinking grapefruit juice while being treated with this medication unless your doctor instructs you otherwise. Grapefruit can increase the amount of certain medications in your bloodstream. Consult your doctor or pharmacist for more details. Inform your doctor if your condition worsens.

Side Effects of Prograf

Shaking, headache, diarrhea, nausea/vomiting, upset stomach, loss of appetite, trouble sleeping, and tingling of the hands/feet may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: mental/mood changes, dizziness, change in the amount of urine, tiredness, pounding heartbeat, hearing problems (such as hearing loss, ringing in the ears), pain/redness/swelling of arms or legs, easy bruising/bleeding, muscle pain/cramp/weakness, yellowing skin/eyes, dark urine, persistent nausea/vomiting, severe stomach/abdominal pain, swelling ankles/feet.

This medication may also increase your risk of getting a rare but very serious (sometimes fatal) brain infection (progressive multifocal leukoencephalopathy-PML). Get medical help right away if any of these rare but very serious side effects occur: clumsiness, loss of coordination, weakness, sudden change in your thinking (such as confusion, difficulty concentrating), difficulty moving your muscles, problems with speech, seizure, vision changes.

Get medical help right away if you have any very serious side effects, including: fainting, fast/irregular heartbeat, severe dizziness, chest/jaw/left arm pain, black stools, vomit that looks like coffee grounds. Tacrolimus may cause your blood pressure to increase. You may be required to check your blood pressure periodically and/or take another medication to control your blood pressure.

Tacrolimus may cause diabetes. Tell your doctor or pharmacist if you experience any of the following symptoms of high blood sugar: increased thirst/hunger, frequent urination. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Before using this medication, tell your doctor or pharmacist your medical history, especially of: mineral imbalances (such as high potassium), kidney disease, any recent/current infections, cancer, liver disease, high blood pressure, diabetes.

Tacrolimus may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using tacrolimus, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using tacrolimus safely.

This medication may increase your risk of developing skin cancer. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen with a high protection factor and wear protective clothing when outdoors. Tacrolimus can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose). This drug may increase your potassium levels. Before using potassium supplements or salt substitutes containing potassium, consult your doctor or pharmacist. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above). During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. This drug passes into breast milk and the effect on a nursing infant is unknown. Discuss the risks and benefits with your doctor before breast-feeding.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: aluminum/magnesium antacid, cyclosporine, sirolimus, temsirolimus, ziprasidone, other drugs that may increase the level of potassium in the blood (such as "water pills" including amiloride, spironolactone), other drugs that weaken the immune system/increase the risk of infection (such as natalizumab, rituximab).

Other medications can affect the removal of tacrolimus from your body, which may affect how tacrolimus works. Examples include caspofungin, cimetidine, danazol, bromocriptine, nefazodone, ethinyl estradiol, methylprednisolone, St. John's wort, azole antifungals (such as itraconazole, voriconazole), calcium channel blockers (such as nifedipine, verapamil), proton pump inhibitors (such as omeprazole, lansoprazole), HIV protease inhibitors (such as nelfinavir, ritonavir), other protease inhibitors (such as boceprevir, telaprevir), rifamycins (such as rifampin, rifabutin), certain anti-seizure drugs such as (carbamazepine, phenobarbital, phenytoin), among others.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea, vomiting, fast or irregular heartbeat, unusual drowsiness or dizziness, and loss of consciousness.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Cost of Prograf

The lowest MyGenericPharmacy.com price for the most common version of Prograf (Tacrolimus) is around $2.22, 63% off the average online retailing price of $180.30.

What is Prograf / Tacrolimus?
Prograf is an immunosuppressant medication containing tacrolimus, used to prevent organ transplant rejection (kidney, liver, heart). It suppresses the immune system to stop it from attacking the transplanted organ.

How Does Prograf Work?
Tacrolimus works by inhibiting calcineurin, a key enzyme in T-cell activation. This reduces the production of interleukin-2 (IL-2) and suppresses immune response.

Benefits of Prograf

1. Prevents organ transplant rejection
2. Strong immunosuppressive effect
3. Improves graft survival
4. Widely used in transplant medicine
5. Can be used long-term under supervision

Dosage & How to Use

1. Taken orally as capsules or given intravenously
2. Dose is individualized based on blood levels
3. Usually taken twice daily
4. Take consistently with or without food (same way each time)
5. Requires regular blood monitoring

Side Effects & Precautions
Common side effects may include:

1. Tremors
2. Headache
3. Nausea
4. High blood pressure
5. Kidney function changes

Precautions:

1. Requires regular blood level monitoring
2. Avoid grapefruit juice (increases drug levels)
3. Monitor kidney function, blood pressure, and glucose
4. Avoid exposure to infections

Who Should Not Take Prograf

1. Patients allergic to tacrolimus
2. Use cautiously in patients with kidney disease
3. Individuals with active infections
4. Use carefully in pregnancy and breastfeeding

Other Information of Prograf :
DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.

MISSPELLINGS OF PROGRAF :
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Prowgraf, Prograhf, Prografe, Prograth, Tacrolimus, Tacrolimus, Tacolimus, Tacrolimas, Tacrolamus, Tacrolmus, Tacrolimus, Takrolimus, Tacrolimous, Tarcrolimus, Tacrolinmus, Tacrolimum, Takrolimas, Tacrolimusx, Takrolimus, 
Tacrolimous, Takrolimous, Tacrolimuss, Tacrolymus, Tacralimus, Takralimus, 
Tacrolimoush.

FAQ

1. What is Tacrolimus (Prograf) and what is it used for?
Tacrolimus is a medicinal drug sold under name the brand Prograf which belongs to a class of medication called Immunosuppressants. This medicine is used in organ transplant surgery where an organ is transplanted from one body to another. Tacrolimus works by minimizing the body defense system's ability i.e. white blood cell(immune system) so that your body accepts a foreign organ when transplanted in your body.

2. When and how to use Tacrolimus?
Tacrolimus comes in a form of tablet/pill that must be taken by mouth usually twice a day or as per your doctor's prescription. The delay between the dosage must be around 12 hours each as per your doctor's direction. Also taking medicine with or without food will be informed by the doctor and the same must be followed always. Do Not crush the tablet or open the capsule rather swallow them whole with water. Dosage is based upon your age, weight, medical condition, immune health etc. Try to take this medicine regularly to get the most benefits from it. Also do not increase the dosage without doctor's consultancy. Pregnant women must avoid this medication as it can harm the unborn. Consult your doctor in case of any confusion or exception.

3. What are side effects of Tacrolimus?
Some of the common side effects observed while medicating with tacrolimus which usually do not required urgent medical attention are itching, headache, nausea, flu-like symptoms, swollen or infected hair follicles, acne, tingling skin, skin burning, stinging, redness or soreness, muscle or back pain, stuffy or runny nose etc. Inform your doctor if these effects persist or do not go away. There are also some serious side effects that need urgent medical attention like, rash, cold sores, swelling of the hands, arms, feet, ankles, or lower legs, chicken pox or other blisters, crusting, oozing, blistering or other signs of skin infection etc.

4. How effective is Tacrolimus?
Tacrolimus is based on your body weight, age and medical condition. For adults, the initial dosage is calculated around 0.075miligrams per kilogram of a person's body weight. These doses must be divided by 2 and must be taken in an interval of 12 hours daily. Your doctor may vary the dosage after examining you. Generally follow the doctor's guideline and leaflet prescription provided for you carefully. Also you must keep informing your doctor about your progress weekly.

5. Does Prograf cause memory loss?
According to a trial of 100 people associated with Prograf, around 4-20 people reported damage in organs which could further cause variation in thinking, shortness of breath, memory loss, confusion, etc. The medicine also causes an allergic reaction that must be informed immediately to the doctor for medical attention.

6. Can Prograf cause hair loss?
For patients that have gone through organ transplants, Prograf has become a new cause for hair loss conditions in such people. However, the condition is not to be observed by every person taking Prograf. Also, the actual nature of this kind of condition is still unknown. 

7. What happens if you take too much Prograf?
Prograf is a kind of medicine that must be taken exactly as prescribed by the doctor. Overdosing of the medicine could severely increase the risk of adverse side effects such as certain types of cancer that include lymph gland cancer and skin cancer.

8. Can Prograf increase creatinine?
Creatinine is a breakdown product of a substance called creatine that is used by muscles to make energy. There are a number of reasons that could cause a rise in creatinine level that include high Prograf or cyclosporine level, acute transplant rejection, the problematic flow of urine from bladder or kidney, etc.

9. What drugs interact with prograf?
Interaction with a medicine generally refers to a change of effectiveness and potential risk of side effects that can develop in the body when two or more different drugs come into contact with one another inside the body. Drugs interacting with Prograf are  sirolimus, temsirolimus, ziprasidone, cyclosporine, aluminum/magnesium antacid, etc.   

10. Does tacrolimus cause erectile dysfunction?
According to the data of immunosuppressant treatment, treatment associated with Prograf was not involved with erectile dysfunction. This might be due to majority of patients were of low mean age when medicated with Prograf.

11. What precautions must be taken before medicating with tacrolimus?
Before starting the medication with tacrolimus, one must inform the doctor regarding allergies related to it, other macrolide medications, or any other allergies as these products may contain some ingredient that causes an allergic reaction inside your body. Inform your doctor if you have a medical history related to the use of therapy associated with light, swollen lymph nodes, skin cancer or other, other skin conditions, kidney disease, skin Infections, etc.